Cas13a (C2c2) ELISA Kit

The Cas13a protein (CRISPR associated protein 13a, C2c2) is part of the Type VI CRISPR-Cas system. When Cas13a is bound to a CRISPR-RNA (crRNA), it forms a crRNA-guided RNA-targeting effector complex. When Cas13a binds a precursor-crRNA (pre-crRNA), Cas13a cust within the crRNA direct repeat in a pre-crRNA to produce a mature Cas13a-crRNA complex. Subsequently, binding of an activator RNA molecule complementary to the crRNA causes Cas13a to cut RNA non-specifically through activation of the enzyme's two higher-eukaryotes-and-prokaryotes nucleotide-binding (HEPN) domains to form a single RNase active site.