Modified Histone Antibodies

Epigenetics is the study of heritable phenotype changes in gene expression that modify DNA, RNA, and protein but do not involve alterations of the nucleotide sequence. Posttranslational modifi cations (PTMs) are the most important method to research epigenetics that apply to proteins. PTMs are marks that provide an extensive regulatory mechanism for cells to signal which genes to turn off and on. Many types and families of proteins are subject to PTMs, but one of the most highly decorated is the histone family of proteins.

Histone packages genomic DNA into nucleosomes, which allows about 2 meters of DNA to be placed in the nucleus of a cell. The nucleosome contains two subunits, each consisting of histone H2A, H2B, H3 and H4. In addition, there is histone H1, commonly referred to as a junctional histone. The most prevalent PTMs found on histones have a crucial role in gene expression, including methylation, acetylation, phosphorylation, and ubiquitination. These markers serve as signals for opening and compressing chromatin, as well as recruitment factors that promote and antagonize transcription.

These modifications of histone can regulate gene expression, which in turn affects chromosome function. CUSABIO provides highly specific histone-modified antibodies that have been validated by ChIP, WB, IHC, IP, etc., and can be used to detect modified histones in specific gene regions. 

Modified Histone Antibodies 검색